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KMID : 0903520040470020265
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2004 Volume.47 No. 2 p.265 ~ p.269
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Antioxidant and Inhibitory Activities on Angiotensin Converting Enzyme in Lysimachia clethroides Duby
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Lee Seung-Eun
Bang Jin-Ki
Seong Nak-Sull
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Abstract
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This study was conducted to develop physiologically active plant materials from medicinal plants. Crude extracts and solvent fractions prepared from Lysimachia cletroides Duby were tested for their antioxidant and antihypertensive activities. For ellucidating antioxidant potential, inhibition rate on linoleic acid peroxidation, as well as scavenging activities on superoxide anion and 1,1-dipicrylphenylhydrazyl (DPPH) radical were evaluated. For analyzing antihypertensive effect, inhibitory activity on angiotensin converting enzyme (ACE) was done. Methanol extract of L. cletroides showed potent inhibition activity of 83% on linoleic acid peroxidation, which was more effective than ?2% of α-tocopherol at 25 μg/ml. Methanol and water extracts exhibited strong scavenging activities of 86~109% and 96~122% on superoxide anion radical which was higher than ?4.2%~69% of ascorbic acid at 5~200 μg/ml. Hexane, ether and ethylacetate fractions possessed 133, 100 and 88% inhibitory activities on ACE at 4,000 μg/ml, respectively. From the results, it was expected that Lysimachia cletroides could be a new antioxidant and antihypertensive resource.
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KEYWORD
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Lysimachia clethroides, antioxidant, ACE inhibitor, radical scavenger
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